Role of B cells in immune-mediated dermatoses. (October 2020)

• Record Type: Journal Article
• Authors: Wang, Wen-Ming; Guo, Lan; Jin, Hong-Zhong
• Is Part Of: Molecular immunology. Volume 126(2020:Oct.)
• Page Start: 95
• Page End: 100
• Publication Date: 2020-10
• Subjects: B cells -- Regulatory B cells -- Psoriasis -- Pemphigus; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2020.07.016
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: Regulatory B cells (Bregs) are immunosuppressive cells that play an important role in the process of immunological tolerance. Regulatory B cell subsets may play a negative role in the pathogenesis of psoriasis, especially IL-10-producing B cells. Dsg3-specific memory B cells and B10 cells might play crucial roles in the pathogenesis and reoccurrence of pemphigus. Further understanding of the role of B cells in immune-mediated dermatoses could lead to new therapeutic targets. Abstract: Although T cells are considered as the central component in immune-mediated diseases, supportive evidence has demonstrated that B cells also contribute to the progression of these diseases. B cells are divided into various subsets according to their secreted cytokines. Different B cell subsets play diverse roles in immune-mediated dermatoses. Regulatory B cells (Bregs) are defined functionally by their ability to secrete IL-10, which has been revealed to contribute to immunological tolerance. Drugs that deplete B cells, such as rituximab, are now used for the treatment of several immune-mediated dermatoses. In this review, we present and discuss the current knowledge on the roles of B cells in several immune-mediate dermatoses including psoriasis, pemphigus, bullous pemphigoid, and dermatomyositis, atopic dermatitis.