Pulmonary ischaemia without pulmonary arterial thrombus in COVID-19 patients receiving extracorporeal membrane oxygenation: a cohort study. Issue 10 (October 2020)

• Record Type: Journal Article
• Authors: Mak, S.M.; Mak, D.; Hodson, D.; Preston, R.; Retter, A.; Camporota, L.; Benedetti, G.
• Is Part Of: Clinical radiology. Volume 75:Issue 10(2020)
• Page Start: 795.e1
• Page End: 795.e5
• Publication Date: 2020-10
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2020.07.006
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : AIM: To evaluate the incidence of pulmonary ischaemia in COVID-19 patients on extracorporeal membrane oxygenation (ECMO), and its correlation with pulmonary artery thrombosis. MATERIALS AND METHODS: Computed tomography (CT) thorax of all patients receiving ECMO with proven COVID-19 pneumonitis between March and May 2020 were analysed for the presence and extension of pulmonary thromboembolic disease. RESULTS: Fifty-one patients were reviewed. The mean (range) age of 45 (26–66) years; 38/51 (74.5%) were men. All patients had severe COVID-19 pneumonitis, and 18/51 (35.3%) had macroscopic thrombosis (15 with associated ischaemia); however, 13/51 (25.5%) patients had ischaemia without associated thrombus. CONCLUSION: The majority of patients with COVID-19 who received ECMO had areas of ischaemia within consolidated lungs, almost half of these without subtending pulmonary artery thrombosis. Although the prognostic significance of these findings is unclear, they are highly suggestive of lung ischaemia due to isolated microvascular immune thrombosis. Highlights: High incidence of pulmonary artery thrombosis in COVID-19 ECMO patients. Lung ischaemia seen in patients with and without visible pulmonary artery thrombus. Ischaemia with no visible thrombus suggest microvascular thrombosis.