Characterization of 3D bifurcations in micro-scan and MRA-TOF images of cerebral vasculature for prediction of intra-cranial aneurysms. (September 2020)

• Record Type: Journal Article
• Authors: Nouri, A.; Autrusseau, F.; Bourcier, R.; Gaignard, A.; L'allinec, V.; Menguy, C.; Véziers, J.; Desal, H.; Loirand, G.; Redon, R.
• Is Part Of: Computerized medical imaging and graphics. Volume 84(2020)
• Publication Date: 2020-09
• Subjects: 3D Graph -- Geometry -- 3D skeleton -- Aneurysm -- Bifurcation characterization -- Micro-CT -- MRA-TOF; Diagnostic imaging -- Periodicals; Imaging systems in medicine -- Periodicals; Diagnosis, Radioscopic -- Data processing -- Periodicals; Diagnostic Imaging -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Diagnostic imaging; Periodicals; Electronic journals; Electronic journals; 616.0754
• DOI: 10.1016/j.compmedimag.2020.101751
• Languages: English
• ISSNs: 0895-6111

Abstract

Graphical abstract: Highlights: We propose a geometrical characterisation of cerebral tree bifurcations. A 3D skeleton associated with a graph provide an accurate bifurcation localization. We show a link between bifurcations' geometry and the formation of aneurysms. The bifurcation angles and the mother artery tortuosity plays important roles. Geometrical estimations were compared with ground truth measurements. Abstract: An aneurysm is a vascular disorder where ballooning may form in a weakened section of the wall in the blood vessel. The swelling of the aneurysm may lead to its rupture. Intra-cranial aneurysms are the ones presenting the higher risks. If ruptured, the aneurysm may induce a subarachnoid haemorrhage which could lead to premature death or permanent disability. In this study, we are interested in locating and characterizing the bifurcations of the cerebral vascular tree. We use a 3D skeletonization combined with a graph-based approach to detect the bifurcations. In this work, we thus propose a full geometric characterisation of the bifurcations and related arteries. Aside from any genetic predisposition and environmental risk factors, the geometry of the brain vasculature may influence the chance of aneurysm formation. Among the main achievements, in this paper, we propose accurate, predictive 3D measurements of the bifurcations and we furthermore estimate the risk of occurrence of an aneurysm on a given bifurcation.