Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis. Issue 9 (22nd July 2020)

• Record Type: Journal Article
• Authors: Yoo, Seung Soo; Lee, Jang Hyuck; Hong, Mi Jeong; Choi, Jin Eun; Kang, Hyo‐Gyoung; Do, Sook Kyung; Kim, Ji Hyun; Baek, Sun Ah; Choi, Sun Ha; Lee, Won Kee; Lee, Yong Hoon; Seo, Hyewon; Lee, Jaehee; Lee, Shin Yup; Cha, Seung Ick; Kim, Chang Ho; Park, Jae Yong
• Is Part Of: Thoracic cancer. Volume 11:Issue 9(2020)
• Page Start: 2698
• Page End: 2703
• Publication Date: 2020-07-22
• Subjects: DTX1 -- response -- rs1732786 -- SCLC -- survival; Chest -- Cancer -- Periodicals; Chest -- Cancer -- Treatment -- Periodicals; Chest -- Surgery -- Periodicals; 616.99494005
• DOI: 10.1111/1759-7714.13566
• Languages: English
• ISSNs: 1759-7706

Abstract

Abstract : Deltex‐1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66, P = 2 × 10 −4 ; hazard ratio = 1.47, 95% CI: 1.17–1.84, P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele ( P = 2 × 10 −7 ). In summary, DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. Key points: Significant findings of the study: DTX1 rs1732786A > G was associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC) in our previous study. What this study adds: DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC). Abstract : DTX1 rs1732786A>G was associated with better prognosis in patients with early‐stage non‐small cell lung cancer, in the previous study. DTX1 rs1732786A>G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer.