Additional pharmacological activity of I‐modulia and generation of two newly designed extracts of Aquaphilus dolomiae culture for dermocosmetic actives. (1st September 2020)

• Record Type: Journal Article
• Authors: Nguyen, T.; Chol, B.; Maitre, M.; Ravard‐Helffer, K.; Farinole, F.; Lestienne, F.; Castex‐Rizzi, N.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 34(2020)Supplement 5
• Page Start: 27
• Page End: 29
• Publication Date: 2020-09-01
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.16546
• Languages: English
• ISSNs: 0926-9959

Abstract

Abstract: Aquaphilus dolomiae (AD) is a unique isolate from Avène Thermal Spring Water. I‐Modulia, the first biotech extract from culture of AD, was used as immune modulator in Th2 inflammatory models. In this short publication, firstly we describe generation of two AD de novo extracts specifically designed for repairing and for neuroinflammation modulation activities which will be described, respectively, in two other articles in this supplement. Finally, for I‐modulia, we describe new data on inhibition of human mast cell degranulation in vitro and its effect on substance P‐induced neurogenic inflammation on ex vivo human skin explants.