Inducing Social Self‐Sorting in Organic Cages To Tune The Shape of The Internal Cavity. (16th July 2020)

• Record Type: Journal Article
• Authors: Abet, Valentina; Szczypiński, Filip T.; Little, Marc A.; Santolini, Valentina; Jones, Christopher D.; Evans, Robert; Wilson, Craig; Wu, Xiaofeng; Thorne, Michael F.; Bennison, Michael J.; Cui, Peng; Cooper, Andrew I.; Jelfs, Kim E.; Slater, Anna G.
• Is Part Of: Angewandte Chemie. Volume 132:Number 38(2020)
• Page Start: 16898
• Page End: 16906
• Publication Date: 2020-07-16
• Subjects: cage compounds -- molecular materials -- multi-component self-assembly -- self-sorting -- supramolecular chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202007571
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Many interesting target guest molecules have low symmetry, yet most methods for synthesising hosts result in highly symmetrical capsules. Methods of generating lower symmetry pores are thus required to maximise the binding affinity in host–guest complexes. Herein, we use mixtures of tetraaldehyde building blocks with cyclohexanediamine to access low‐symmetry imine cages. Whether a low‐energy cage is isolated can be correctly predicted from the thermodynamic preference observed in computational models. The stability of the observed structures depends on the geometrical match of the aldehyde building blocks. One bent aldehyde stands out as unable to assemble into high‐symmetry cages‐and the same aldehyde generates low‐symmetry socially self‐sorted cages when combined with a linear aldehyde. We exploit this finding to synthesise a family of low‐symmetry cages containing heteroatoms, illustrating that pores of varying geometries and surface chemistries may be reliably accessed through computational prediction and self‐sorting. Abstract : A sea of expanding shapes : A combined experimental–computational approach enabled the synthesis of low‐symmetry imine cages from mixtures of tetraaldehyde building blocks. This "social self‐sorting" approach was applied to obtain a family of new cages containing heteroatoms, showing that pores of varying geometries and surface chemistries may be reliably accessed.