Synthesis of amino‐cosubstituted polyorganophosphazenes and fabrication of their nanoparticles for anticancer drug delivery. Issue 46 (3rd June 2020)

• Record Type: Journal Article
• Authors: Khan, Rizwan Ullah; Yu, Haojie; Wang, Li; Teng, Lisong; Zain‐ul‐Abdin, ; Nazir, Ahsan; Fahad, Shah; Elshaarani, Tarig; Haq, Fazal; Shen, Di
• Is Part Of: Journal of applied polymer science. Volume 137:Issue 46(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-03
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.49424
• Languages: English
• ISSNs: 0021-8995

Abstract

Abstract: The development of safe drug carriers is cardinal in cancer therapy, which can target the cancer cells and release the loaded drug on‐demand without damaging the healthy cells of the body. In our work, we synthesized three different biodegradable polymers, poly[(ethyl aminobezoate) (ethyl glycinato) phosphazenes] (PABGPs), in different mole ratio of side groups. The successful synthesis of these PABGPs was confirmed by 1 H NMR, 31 P NMR, FT‐IR, and gel permeation chromatography. These PABGPs were fabricated into drug (camptothecin, CPT, a hydrophobic anticancer drug) loaded nanoparticles. These drug‐loaded nanoparticles showed good drug release behaviors under normal physiological conditions (pH 7.4 and temperature 37°C). These PABGPs‐based nanoparticles may find their application as effective drug carriers for cancer therapy. Abstract :