Effects of ipragliflozin on the development and progression of kidney disease in patients with type 2 diabetes: An analysis from a multicenter prospective intervention study. Issue 5 (25th April 2020)

• Record Type: Journal Article
• Authors: Matsuba, Ikuro; Kawata, Takehiro; Iemitsu, Kotaro; Asakura, Taro; Amemiya, Hikaru; Ishikawa, Masashi; Ito, Syogo; Kaneshiro, Mizuki; Kanamori, Akira; Kubota, Akira; Shinoda, Kazuaki; Takai, Masahiko; Takuma, Tetsuo; Takihata, Masahiro; Takeda, Hiroshi; Tanaka, Keiji; Matsuzawa, Yoko; Machimura, Hideo; Minagawa, Fuyuki; Minami, Nobuaki; Mokubo, Atsuko; Miyakawa, Masaaki; Terauchi, Yasuo; Tanaka, Yasushi
• Is Part Of: Journal of diabetes investigation. Volume 11:Issue 5(2020)
• Page Start: 1248
• Page End: 1257
• Publication Date: 2020-04-25
• Subjects: Diabetic nephropathy -- Ipragliflozin -- Sodium–glucose cotransporter 2 inhibitor; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.13248
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: Aims/Introduction: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long‐term treatments are available. Methods: This was an investigator‐initiated multicenter prospective intervention study in which ipragliflozin (50 mg) was administered once daily, and glycemic control, estimated glomerular filtration rate (eGFR) and adverse events were evaluated until 104 weeks after starting research. Results: There were 407 patients analyzed. In the eGFR ≥90 group and eGFR ≥60 to <90 group, eGFR had significantly decreased compared with baseline at all time points from 4 to 104 weeks. There were significant increases in the eGFR ≥45 to <60 groups compared with baseline at 36 weeks (2.3 ± 1.0) and 52 weeks (2.6 ± 1.2). Comparison between the eGFR <60, urine albumin‐to‐creatinine ratio >300 group and the eGFR <60, urine albumin‐to‐creatinine ratio <300 group showed a greater reduction in eGFR in the former (−5.4 ± 2.4 vs 3.3 ± 1.1) at 12 weeks and was maintained to 104 weeks. In any group, eGFR did not significantly decrease until 104 weeks compared with 4 weeks. The urine albumin‐to‐creatinine ratio after 52 weeks and after 104 weeks was significantly decreased compared with baseline in the eGFR ≥90 group. Conclusions: Ipragliflozin lowers eGFR and corrects hyperfiltration in patients with high eGFR (eGFR ≥60). In patients with low eGFR (eGFR ≥30 to <60), ipragliflozin has the possibility of increasing eGFR and exerting a renoprotective effect. Abstract : In the estimated glomerular filtration rate (eGFR) ≥90 group and eGFR ≥60 to <90 group, eGFR had significantly decreased compared with baseline at all time points from 4 to 104 weeks. There were significant increases in the eGFR ≥45 to <60 groups compared with baseline at 36 weeks (2.3 ± 1.0) and 52 weeks (2.6 ± 1.2). In each group, there was no significant change compared with 12 weeks at all time points between 24 and 104 weeks.