Alcohol‐induced impaired insulin secretion in a Japanese population: 5‐year follow up in the Gifu Diabetes Study. Issue 5 (4th May 2020)

• Record Type: Journal Article
• Authors: Ueda, Natsumi; Yamamoto, Mayumi; Nakamura, Mitsuhiro; Motooka, Yumi; Nakayama, Yoko; Nonoyama, Yukiko; Oba, Shino; Horikawa, Yukio; Nagata, Chisato; Yabe, Daisuke
• Other Names: Adachi Kayoko investigator.; Araki Mitsuyo investigator.; Chimori Kenzo investigator.; Daidoh Hisashi investigator.; Fushimi Katumasa investigator.; Goshima Eiichi investigator.; Hayashi Hideo investigator.; Hayashi Makoto investigator.; Imai Tatsuyuki investigator.; Ishii Maho investigator.; Izai Midori investigator.; Kamikubo Keita investigator.; Kanoh Yoshinori investigator.; Kitada Masahisa investigator.; Kojima Noriko investigator.; Kojima Toshihiro investigator.; Komaki Takuji investigator.; Kosaka Joji investigator.; Maekawa Hiroyuki investigator.; Murayama Masanori investigator.; Matsuda Masafumi investigator.; Matsui Ikuo investigator.; Morimoto Yoshikazu investigator.; Morioka Yasuo investigator.; Murase Hiroshi investigator.; Nagai Kotaro investigator.; Nagashima Toshihiko investigator.; Noda Nobuteru investigator.; Noritake Nobuyasu investigator.; Ohmae Kazuhiro investigator.; Ozeki Shigehiko investigator.; Sakata Shigeki investigator.; Sarui Hiroshi investigator.; Sato Mayumi investigator.; Sugimoto Miyuki investigator.; Suzuki Eiji investigator.; Takeda Noriyuki investigator.; Totani Rieko investigator.; Wada Takaaki investigator.; Wada Yuji investigator.; Yokoyama Michie investigator.; Yoshino Kouji investigator.;
• Is Part Of: Journal of diabetes investigation. Volume 11:Issue 5(2020)
• Page Start: 1207
• Page End: 1214
• Publication Date: 2020-05-04
• Subjects: Alcohol consumption -- Insulin secretion -- Japanese; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.13260
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: Aims/Introduction: Although moderate alcohol consumption lowers the risk of type 2 diabetes in European populations, the same cannot be assumed for Japanese patients with diabetes related to low insulin secretion rather than resistance. We aimed to evaluate the effects of daily alcohol consumption on glucose tolerance and diabetes development risk in Japanese populations. Materials and methods: This retrospective study randomly enrolled 452 men and 659 women aged 40–78 years in 2005 (Gifu, Japan). The participants completed a 75‐g oral glucose tolerance test and medical questionnaire. The homeostasis model assessment of insulin resistance, homeostasis model assessment of β‐cell function and insulinogenic index were used to estimate insulin sensitivity and secretion. The relationships between alcohol consumption and these parameters were analyzed using logistic regression after adjusting for potential confounders. The 5‐year changes in hemoglobin A1c levels were also evaluated. Results: The adjusted odds ratios for elevated homeostasis model assessment of β‐cell function values (<40%) in the 0–19.9 g/day, 20.0–39.9 g/day and ≥ 40 g/day alcohol consumption groups were 0.98, 1.46 and 2.68, respectively. Alcohol consumption induced a significant decrease in the insulin secretion level among the ≥40 g/day drinkers, especially in men. However, there was no risk of increased insulin resistance based on the homeostasis model assessment of insulin resistance (<2.5) results. The 5‐year risk of elevated hemoglobin A1c levels (≥6.5%) was increased according to increase in alcohol consumption in both men and women. Conclusions: Daily alcohol consumption was associated with reduced insulin secretion and an increased diabetes development risk in Japanese populations. Abstract : Participants (452 men and 659 women aged 40–78 years) were randomly enrolled and completed a 75‐g oral glucose tolerance test and medical questionnaire. The relation between alcohol intake and insulin secretion / resistance were analyzed. The 5‐year changes in HbA1c levels were also evaluated. Daily alcohol consumption was associated with reduced insulin secretion and an increased diabetes development risk in Japanese populations.