A biocompatible cellulose-nanofiber-based multifunctional material for Fe3+ detection and drug delivery. Issue 34 (3rd August 2020)

• Record Type: Journal Article
• Authors: Wang, Lei; Zhu, Hongxiang; Xu, Guotao; Hou, Xudong; He, Hui; Wang, Shuangfei
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 34(2020)
• Page Start: 11796
• Page End: 11804
• Publication Date: 2020-08-03
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Optical materials -- Research -- Periodicals; Electronics -- Materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tc02604b
• Languages: English
• ISSNs: 2050-7526

Abstract

Abstract : A nanoscale cellulose-nanofiber-based multifunctional material (CNF-DA) with excellent biocompatibility was prepared, which could be used to drug delivery, antibacterial properties, and spectrophotometric and solid colorimetric Fe 3+ sensing. Abstract : Although biomass-based materials offer several advantages as matrices for the development of multifunctional sensors, they have rarely been applied for dual-function solid colorimetric and spectrophotometric sensing. Herein, a nanoscale cellulose-nanofiber-based multifunctional material (CNF-DA) with excellent biocompatibility was prepared by grafting dopamine (DA) onto cellulose nanofibers with carboxyl groups (CNF-COOH) using an amidation reaction. Owing to the morphological diversity of as-prepared CNF-DA ( e.g., a nanoscale homogeneous suspension, solid nanofibers, and an aerogel), multifunctional properties, including drug delivery, antibacterial properties, and spectrophotometric and solid colorimetric Fe 3+ sensing, were realized. Solid CNF-DA exhibited excellent selectivity and sensitivity toward Fe 3+ with a remarkable color change from off-white to dark green and a limit of detection (LOD) of 5 × 10 −7 mol L −1 . Furthermore, CNF-DA was applied as a UV spectrophotometric sensor for Fe 3+ in aqueous solution with an LOD of 6.6 × 10 −11 mol L −1 . CNF-DA also exhibited drug delivery and antibacterial properties owing to an abundance of hydroxyl groups and the high porosity of the nanofiber. The maximum drug loading capacity of CNF-DA and the release rate of doxorubicin were 879.09 mg g −1 and 80% at pH 1.2, respectively. Thus, multifunctional CNF-DA has broad application prospects in the areas of food science and biological medicine.