Prediction of nodal staging in breast cancer patients with 1-2 sentinel nodes in the Z0011 era. Issue 35 (28th August 2020)

• Record Type: Journal Article
• Authors: Corsi, Fabio; Sorrentino, Luca; Albasini, Sara; Bossi, Daniela; Morasso, Carlo; Villani, Laura; Truffi, Marta
• Other Names: Masoomi. Michael section editor.
• Is Part Of: Medicine. Volume 99:Issue 35(2020)
• Publication Date: 2020-08-28
• Subjects: breast cancer -- axillary nodal status -- nomogram; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000021721
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The aim of this study was to provide an innovative nomogram to predict the risk of >2 positive nodes in patients fulfilling the Z0011 criteria with 1-2 sentinel lymph nodes (SLNs) only retrieved. From 2007 to 2017, at the Breast Unit of ICS Maugeri Hospital 271 patients with 1-2 macrometastatic SLNs, fulfilling the Z0011 criteria, underwent axillary dissection and were retrospectively reviewed. A mean of 1.5 SLNs per patient were identified and retrieved. One hundred eighty-seven (69.0%) had 1-2 positive nodes, and 84 (31.0%) had >2 metastatic nodes. Independent predictors of axillary status were: positive SLNs/retrieved SLNs ratio (odds ratio [OR] 10.95, P = .001), extranodal extension (OR 5.51, P = .0002), and multifocal disease (OR 2.9, P = .003). A nomogram based on these variables was constructed (area under curve after bootstrap = 0.74). The proposed nomogram might select those patients fulfilling the Z0011 criteria, with 1-2 SLNs harvested, in whom a high axillary tumor burden is expected, aiding to guide adjuvant treatments. Abstract : Supplemental Digital Content is available in the text