Efficacy and safety of Xiaoaiping injection for liver cancer: A protocol for systematic review and meta-analysis. Issue 35 (28th August 2020)

• Record Type: Journal Article
• Authors: Hou, Daorui; Xiong, Jian; Li, Ya; Peng, Yahui; Xiong, Lu
• Is Part Of: Medicine. Volume 99:Issue 35(2020)
• Publication Date: 2020-08-28
• Subjects: liver cancer -- protocol -- systematic review and meta-analysis -- Xiaoaiping; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000021993
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Xiaoaiping injection, extracted from the Chinese herb Marsdenia tenacissima (Roxb.) Wight et Arn ., is a broad-spectrum anti-tumor drug and has been widely used for the treatment of liver cancer in China. The aim of this study is to systematically investigate the efficacy and safety of Xiaoaiping injection for the treatment of liver cancer. Methods and analysis: Seven electronic databases including the Cochrane Library, PubMed, Excerpt Medica Database, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Scientific Journal Database, and Wanfang Database will be systematically retrieved for data extraction from their inceptions to August 2020. Cochrane Risk of Bias tool will be used to assess the risk of bias of included studies. The RevMan 5.4 and Stata 16.0 software will be applied for statistical analyses. Statistical heterogeneity will be computed by I 2 tests. Sensitivity analysis will be conducted to evaluate the stability of the results. The publication bias will be evaluated by funnel plots and Eggers test. The quality of evidence will be assessed by the GRADE system. Results: The results of our research will be published in a peer-reviewed journal. Conclusion: The conclusion of this study will provide helpful evidence of the effect and safety of Xiaoaiping injection for the treatment of liver cancer in clinical practice. OSF registration number: 10.17605/OSF.IO/9BD6A.