Surgical and oncologic outcomes of minimally invasive surgery for stage I high-grade endometrial cancer. (September 2020)

• Record Type: Journal Article
• Authors: Nasioudis, Dimitrios; Heyward, Quetrell D.; Haggerty, Ashley F.; Giuntoli II, Robert L.; Burger, Robert A.; Morgan, Mark A.; Ko, Emily M.; Latif, Nawar A.
• Is Part Of: Surgical oncology. Volume 34(2020)
• Page Start: 7
• Page End: 12
• Publication Date: 2020-09
• Subjects: Endometrial neoplasms -- Laparoscopes -- Laparotomy; Cancer -- Surgery -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Electronic journals; 616.994059
• DOI: 10.1016/j.suronc.2020.02.015
• Languages: English
• ISSNs: 0960-7404

Abstract

Abstract: Objective: To evaluate the prevalence and outcomes of minimally invasive surgery for stage I high grade endometrial cancer. We hypothesized that route of surgery is not associated with survival. Materials: Patients diagnosed between 2010 and 2014, with stage I grade 3 endometrioid, serous, clear cell and carcinosarcoma endometrial carcinoma, who underwent hysterectomy with lymphadenectomy were drawn from the National Cancer Database. Patients converted to open surgery were excluded. Overall survival was assessed with Kaplan-Meier curves and compared with the log-rank test. A Cox model was constructed to control for confounders. Results: A total of 12852 patients were identified. The rate of minimally invasive surgery was 62.2%. An increase in the use between 2010 and 2014 was noted (p < 0.001). Open surgery was associated with longer hospital stay (median 3 vs 1 day, p < 0.001), higher 30-day unplanned re-admission rate (4.5% vs 2.4%, p < 0.001) and 30-day mortality (0.6% vs 0.3%, p = 0.008). There was no difference in overall survival between patients who had open or minimally invasive surgery, p = 0.22; 3-yr overall survival rates were 83.7% and 84.4% respectively. After controlling for patient age, tumor histology, substage, type of insurance, type of reporting facility, receipt of radiation therapy and chemotherapy, extent of lymphadenectomy, the presence of comorbidities and personal history of another tumor, minimally invasive surgery was not associated with a worse survival (hazard ratio: 1.06, 95% confidence interval: 0.97, 1.15). Conclusions: Minimally invasive surgery for patients with stage I high grade endometrial cancer, was associated with superior short-term outcomes with no difference in overall survival noted. Highlights: Rate of MIS use for stage I high grade endometrial cancer was 62.2%. MIS was associated with superior short term surgical outcomes. There was no difference in 3-yr OS between MIS and open surgery.