3D printing tissue-mimicking materials for realistic transseptal puncture models. (October 2020)
- Record Type:
- Journal Article
- Title:
- 3D printing tissue-mimicking materials for realistic transseptal puncture models. (October 2020)
- Main Title:
- 3D printing tissue-mimicking materials for realistic transseptal puncture models
- Authors:
- Bezek, Lindsey B.
Cauchi, Matthew P.
De Vita, Raffaella
Foerst, Jason R.
Williams, Christopher B. - Abstract:
- Abstract: Applications of additive manufacturing (commonly referred to as 3D printing) in direct fabrication of models for pre-surgical planning, functional testing, and medical training are on the rise. However, one current limitation to the accuracy of models for cardiovascular procedural training is a lack of printable materials that accurately mimic human tissue. Most of the available elastomeric materials lack mechanical properties representative of human tissues. To address the gap, the authors explore the multi-material capability of material jetting additive manufacturing to combine non-curing and photo-curing inks to achieve material properties that more closely replicate human tissues. The authors explore the impact of relative material concentration on tissue-relevant properties from puncture and tensile testing under submerged conditions. Further, the authors demonstrate the ability to mimic the mechanical properties of the fossa ovalis, which proves beneficial for accurately simulating transseptal punctures. A fossa ovalis mimic was printed and assembled within a full patient-specific heart model for validation, where it exhibited accuracy in both mechanical properties and geometry. The explored material combination provides the opportunity to fabricate future medical models that are more realistic and better suited for pre-surgical planning and medical student training. This will ultimately guide safer, more efficient practices. Graphical abstract: Image 1Abstract: Applications of additive manufacturing (commonly referred to as 3D printing) in direct fabrication of models for pre-surgical planning, functional testing, and medical training are on the rise. However, one current limitation to the accuracy of models for cardiovascular procedural training is a lack of printable materials that accurately mimic human tissue. Most of the available elastomeric materials lack mechanical properties representative of human tissues. To address the gap, the authors explore the multi-material capability of material jetting additive manufacturing to combine non-curing and photo-curing inks to achieve material properties that more closely replicate human tissues. The authors explore the impact of relative material concentration on tissue-relevant properties from puncture and tensile testing under submerged conditions. Further, the authors demonstrate the ability to mimic the mechanical properties of the fossa ovalis, which proves beneficial for accurately simulating transseptal punctures. A fossa ovalis mimic was printed and assembled within a full patient-specific heart model for validation, where it exhibited accuracy in both mechanical properties and geometry. The explored material combination provides the opportunity to fabricate future medical models that are more realistic and better suited for pre-surgical planning and medical student training. This will ultimately guide safer, more efficient practices. Graphical abstract: Image 1 Highlights: Medical models with tailored material properties enable realistic surgical simulations. Many anatomic models lack tissue-mimicking traits due to limited material selection. Material jetting non-curing and photo-curing inks creates tissue-mimicking materials. A 3D printed fossa ovalis mimic enables accurate simulation of transseptal punctures. … (more)
- Is Part Of:
- Journal of the mechanical behavior of biomedical materials. Volume 110(2020)
- Journal:
- Journal of the mechanical behavior of biomedical materials
- Issue:
- Volume 110(2020)
- Issue Display:
- Volume 110, Issue 2020 (2020)
- Year:
- 2020
- Volume:
- 110
- Issue:
- 2020
- Issue Sort Value:
- 2020-0110-2020-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-10
- Subjects:
- 3D printing -- Additive manufacturing -- Tissue-mimic -- Fossa ovalis -- Transseptal puncture -- Cardiology
Biomedical materials -- Periodicals
Biomedical materials -- Mechanical properties -- Periodicals
Biomedical materials
Biomedical materials -- Mechanical properties
Periodicals
Electronic journals
610.28 - Journal URLs:
- http://www.sciencedirect.com/science/journal/17516161 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.jmbbm.2020.103971 ↗
- Languages:
- English
- ISSNs:
- 1751-6161
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5015.809000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 13983.xml