Development of photo- and chemo-stable near-infrared-emitting dyes: linear-shape benzo-rosol and its derivatives as unique ratiometric bioimaging platforms. Issue 33 (13th August 2020)

• Record Type: Journal Article
• Authors: Dai, Mingchong; Reo, Ye Jin; Song, Chang Wook; Yang, Yun Jae; Ahn, Kyo Han
• Is Part Of: Chemical science. Volume 11:Issue 33(2020)
• Page Start: 8901
• Page End: 8911
• Publication Date: 2020-08-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0sc03314f
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : NIR-emitting benzo-rosol and -rosamine dyes offer novel ratiometric imaging platforms with high pohoto- and chemo-stability. Abstract : Microscopic imaging aided with fluorescent probes has revolutionized our understanding of biological systems. Organic fluorophores and probes thus continue to evolve for bioimaging applications. Fluorophores such as cyanines and hemicyanines emit in the near-infrared (NIR) region and thus allow deeper imaging with minimal autofluorescence; however, they show limited photo- and chemo-stability, demanding new robust NIR fluorophores. Such photo- and chemo-stable NIR fluorophores, linear-shape π-extended rosol and rosamine analogues, are disclosed here which provide bright fluorescence images in cells as well as in tissues by confocal laser-scanning microscopy. Furthermore, they offer unique ratiometric imaging platforms for activatable probes with dual excitation and dual emission capability, as demonstrated with a 2, 4-dinitrophenyl ether derivative of benzo-rosol.