Restless legs syndrome: A new comorbidity in idiopathic pulmonary fibrosis. (August 2020)

• Record Type: Journal Article
• Authors: Varone, Francesco; Friello, Ludovica; Di Blasi, Chiara; Sgalla, Giacomo; Luigetti, Marco; Iovene, Bruno; Richeldi, Luca; Della Marca, Giacomo; Brunetti, Valerio
• Is Part Of: Respiratory medicine. Volume 170(2020)
• Publication Date: 2020-08
• Subjects: Restless legs syndrome -- Idiopathic pulmonary fibrosis -- Sleep quality -- Interstitial lung disease -- Sleep-related movements disorders; IPF Idiopathic pulmonary fibrosis -- RLS Restless legs syndrome -- COPD Chronic obstructive pulmonary disease -- OSAS Obstructive sleep apnea syndrome -- PSQI Pittsburgh Sleep Quality Index; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2020.105982
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Objective: Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical features of RLS in a cohort of IPF patients. Methods: Fifty patients with diagnosis of IPF were prospectively enrolled. RLS was diagnosed using the validated 5-item RLS criteria. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index. The prevalence of RLS in the IPF group was compared to that observed in a group of 293 patients referred for suspect of sleep disorders. The relationships between RLS and clinical parameters were determined using multivariate logistic regression. Results: Prevalence of RLS in the IPF group was significantly higher than in the control population of patients referred for sleep disorders (IPF: 24%, controls 10%: χ 2 6.49, p = 0.011). Higher PSQI score confirmed to be associated with RLS after adjusting for demographics and clinical parameters of disease severity (OR = 1.38, 95%CI 1.08–1.76; p = 0.01). Conclusions: RLS is highly prevalent in IPF and significantly worsen sleep quality in these patients. The benefit/risk ratio of a specific therapeutic intervention for RLS in IPF should be assessed in further prospective research. Highlights: Current Knowledge/Study Rationale: Sleep quality is compromised in IPF patients. Results: RLS is prevalent and severe in IPF and concurs to worsen sleep quality. Study impact: Treatment of RLS in patients with IPF could ameliorate sleep quality and, in turn, quality of life.