A new ocotillol-type ginsenoside from stems and leaves of Panax quinquefolium L. and its anti-oxidative effect on hydrogen peroxide exposed A549 cells. Issue 17 (1st September 2020)

• Record Type: Journal Article
• Authors: Qi, Zeng; Wang, Zhenzhou; Zhou, Baisong; Fu, Shuilian; Hong, Tie; Li, Pingya; Liu, Jinping
• Is Part Of: Natural product research. Volume 34:Issue 17(2020)
• Page Start: 2474
• Page End: 2481
• Publication Date: 2020-09-01
• Subjects: 12-one-pseudoginsenoside F11 -- Panax quinquefolium L. -- A549 cells -- antioxidant activity -- Nrf2/HO-1; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1543677
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new ocotillol-type ginsenoside, namely 12-one-pseudoginsenoside F11 (12-one-PF11 ), was isolated from stems and leaves of Panax quinquefolium, whose structure was elucidated 6- O -[ α -L-rhamnopyranosyl-(1-2)- β -D-glucopyranosyl]-dammar-12-one-20S, 24R-epoxy-3 β, 6 α, 25-triol. 12-one-PF11 significantly suppressed hydrogen peroxide induced oxidative stress in human lung carcinoma A549 cells. As compared with model group, 12-one-PF11 improved cell viability of A549 cells in a dose-dependent manner, and significantly decreased the generation of malondialdehyde (MDA) and increased production of superoxide dismutase (SOD) and glutathione (GSH) and protein expression levels of nuclear related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) in A549 cells. Graphical Abstract: