Cytotoxic triquinane-type sesquiterpenoids from the endophytic fungus Cerrena sp. A593. Issue 17 (1st September 2020)

• Record Type: Journal Article
• Authors: Liu, Hong-Xin; Tan, Hai-Bo; Chen, Yu-Chan; Li, Sai-Ni; Li, Hao-Hua; Zhang, Wei-Min
• Is Part Of: Natural product research. Volume 34:Issue 17(2020)
• Page Start: 2430
• Page End: 2436
• Publication Date: 2020-09-01
• Subjects: Cerrena sp. -- cytotoxicity -- Pogostemon cablin -- sesquiterpenoids; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1539977
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The culture broth of Cerrena sp. A593, which was isolated from Pogostemon cablin, showed potent cytotoxicity against several human tumor cell lines. The following chemical study resulted in the isolation of two new triquinane-type sesquiterpenoids, named cerrenins D (1) and E (2 ), along with two known compounds plerocybellone A (3 ) and chloriolin B (4 ). Their structures were fully assigned with the aid of extensive spectroscopic analysis ( 1 H and 13 C NMR, HSQC, HMBC, 1 H- 1 H COSY, HRESIMS, and IR) and data from the literature. Moreover, cytotoxic activity in vitro of compounds 1 –4 were evaluated against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound 1 exhibited weak growth inhibitory activity against all the four tumor cell lines with IC50 values of 41.01, 14.43, 29.67, 44.32 μM. Graphical Abstract: