In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities. Issue 16 (17th August 2020)

• Record Type: Journal Article
• Authors: Azad, Abul Kalam; Laboni, Farhina Rahman; Rashid, Harun; Ferdous, Sahena; Rashid, Shah Samiur; Kamal, Nurkhalida; Labu, Zubair Khalid; Islam, M. S.; Islam Sarker, Zaidul
• Is Part Of: Natural product research. Volume 34:Issue 16(2020)
• Page Start: 2394
• Page End: 2397
• Publication Date: 2020-08-17
• Subjects: Cuscuta reflexa -- thrombolytic -- antioxidant -- membrane stabilizing -- anti-microbial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1538216
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g). Graphical Abstract: