Structural features of an acidic polysaccharide with the potential of promoting osteoblast differentiation from Lycium ruthenicum Murr. Issue 16 (17th August 2020)

• Record Type: Journal Article
• Authors: Wang, Shu-Qi; Liu, Bing; Liu, Su; Xie, Song-Zi; Pan, Li-Hua; Zha, Xue-Qiang; Li, Qiang-Ming; Luo, Jian-Ping
• Is Part Of: Natural product research. Volume 34:Issue 16(2020)
• Page Start: 2249
• Page End: 2254
• Publication Date: 2020-08-17
• Subjects: Lycium ruthenicum Murr. -- acidic polysaccharide -- osteoblast differentiation -- structure elucidation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1452014
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The enhanced osteoblast differentiation is beneficial to the prevention of osteoporosis. In this study, a homogeneous polysaccharide (LRP-S2A) with the potential of promoting osteoblast differentiation was obtained from the fruits of Lycium ruthenicum, a traditional herb for treatment of postmenopausal metabolic disorders. Structural identification indicated that LRP-S2A, with a relative molecular weight of 2.65 × 10 6 Da and an uronic acid content of 41.8%, contained Rha, Ara, Gal, Glc and GlcA in a molar ratio of 1.00 : 2.07 : 0.57 : 2.59 : 4.33 and was composed of a backbone consisting of 6-O-Me-α-(1→4)-D-Glc p A, 2-O-acetyl-α-(1→4)-D-Glc p, α-(1→2, 4)-L-Rha p, β-(1→3)-D-Gal p andα-(1→3, 5)-L-Ara f, and some branches consisting of 6-O-Me-α-(1→4)-D-Glc p A and terminal α-L-Ara f . These results suggested that LRP-S2A with the potential of promoting osteoblast differentiation was a new acidic polysaccharide. Abstract :