Synthesis and anticancer property of an octanuclear Mn(III) compound based on pyrazole bifunctional ligand. Issue 12 (17th June 2020)

• Record Type: Journal Article
• Authors: Xu, Hongliang; Li, Xinchen; Zhang, Xujing; Peng, Long; Zou, Dengfeng; Yang, Jie
• Is Part Of: Journal of coordination chemistry. Volume 73:Issue 12(2020)
• Page Start: 1806
• Page End: 1816
• Publication Date: 2020-06-17
• Subjects: Octanuclear -- Mn(III) -- HeLa -- in vitro; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2020.1793137
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: Herein, an octanuclear complex [Mn8 (μ4 -O)4 (phpy)8 (MeOH)4 ]·MeOH·H2 O based on 5-(2-hydroxyphenyl)-3-pyrazole (HphpyH) has been successfully synthesized and characterized. The compound can self-assemble to form nanoparticles (NPs) by nanoprecipitation with PEG-5000 . [Mn8 (μ4 -O)4 (phpy)8 (MeOH)4 ]·MeOH·H2 O NPs have a low IC50 (half maximal inhibitory concentration) of only 44 μg/mL (2.3 μM) on HeLa cells. The results show that [Mn8 (μ4 -O)4 (phpy)8 (MeOH)4 ]·MeOH·H2 O NPs are able to inhibit cell proliferation and migration in vitro . Graphical Abstract: Abstract :