Copper(i)-catalyzed intermolecular cyanoarylation of alkenes: convenient access to α-alkylated arylacetonitriles. Issue 27 (30th June 2020)

• Record Type: Journal Article
• Authors: Chen, Xin-Jie; Gui, Qing-Wen; Yi, Rongnan; Yu, Xianyong; Wu, Zhi-Lin; Huang, Ying; Cao, Zhong; He, Wei-Min
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 27(2020)
• Page Start: 5234
• Page End: 5237
• Publication Date: 2020-06-30
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01055c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient method for the synthesis of α-alkylated arylacetonitriles through Cu(i )-catalyzed cyanoarylation of alkenes with diaryliodonium salts and tetra -butylammonium cyanide was established. Abstract : A novel Cu(i )-catalyzed intermolecular cyanoarylation of alkenes with diaryliodonium salts as a radical arylating reagent and tetra -butylammonium cyanide as an electrophilic cyanating reagent was established. A broad range of α-alkylated arylacetonitriles were efficiently constructed in good to excellent yields under base- and oxidant-free and mild conditions.