Different antifouling effects of random and block copolymers comprising 2-methacryloyloxyethyl phosphorylcholine and dodecyl methacrylate. (5th August 2020)

• Record Type: Journal Article
• Authors: Kojima, Chie; Katayama, Risa; Lien Nguyen, Thi; Oki, Yuto; Tsujimoto, Ayako; Yusa, Shin-ichi; Shiraishi, Kohei; Matsumoto, Akikazu
• Is Part Of: European polymer journal. Volume 136(2020)
• Publication Date: 2020-08-05
• Subjects: MPC polymer -- Dodecyl -- Antifouling -- Composition -- Block copolymer; AIBN 22′-azobis(isobutyronitrile) -- BMA butyl methacrylate -- bPMB block poly(MPC-co-BMA) -- bPMD block poly(MPC-co-DMA) -- CPA 4-cyano-4-[[(dodecylthio)carbonothioyl]thio]pentanoic acid] -- DDS drug delivery systems -- DMA dodecyl methacrylate -- DP degree of polymerization -- GPC gel permeation chromatography -- MPC 2-methacryloyloxyethyl phosphorylcholine -- PMPC-RAFT the MPC polymer with the RAFT end -- RAFT reversible addition−fragmentation chain transfer -- rPMB random poly(MPC-co-BMA) -- rPMD random poly(MPC-co-DMA) -- SLS static light scattering -- SPM scanning probe microscopy -- THF tetrahydrofuran -- FBS fetal bovine serum -- DLS dynamic light scattering; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2020.109932
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Random and block poly(MPC-co-dodecyl methacrylate)s (rPMDs and bPMDs) were synthesized. Short rPMDs with different compositions were stably coated at the substrate but bPMDs were not. Short rPMDs with different compositions showed efficient antifouling effects. Short rPMDs with 34 and 92 mol% in MPC did not form hydrophobic domains. Abstract: Copolymers comprising 2-methacryloyloxyethyl phosphorylcholine (MPC) are useful in the production of biomedical devices because of the antifouling effects. As copolymers of MPC with a hydrophobic comonomer are used as a coating agent, their composition, molecular weight, and sequence possibly impact their antifouling effect. In this study, random and block PMDs (rPMDs and bPMDs, respectively) with different compositions were synthesized, and their antifouling effects were examined. Short rPMDs (approximately 50 kDa) with different MPC compositions, from 34 mol% to 85 mol%, were stably coated and suppressed the adhesion of HeLa cells efficiently. rPMDs with 66 mol% and 85 mol% in MPC showed hydrophobic domains at the surface, to which macrophage-like RAW264 cells were adhered. However, rPMDs with 34 mol% and 92 mol% in MPC showed neither hydrophobic domains nor the adhesion of RAW264 cells after the 1-day culture. On the other hand, the antifouling effects of bPMDs were lower than those of rPMDs because of the micelle formation. Therefore, our results suggest that a variety of rPMDs with different MPC contents and different molecular weights can be used as coating agents, which are different from the poly(MPC- co -butyl methacrylate)s used conventionally.