Reduction of the occurrence of occult HBV infection in infants by increasing the dose of hepatitis B vaccine: a large prospective cohort study. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Li, Authors: Yi; Liu, Zhixiu; Song, Yarong; Xiao, Yiwei; Jiang, Jing; Li, Lili; Zhai, Xiangjun; Liu, Jianxun; Duan, Zhongping; Ding, Feng; Liu, Jia; Zhuang, Hui; Zhu, Liguo; Jiang, Jie; Zou, Huaibin; Wang, Jie; Li, Jie
• Is Part Of: Emerging microbes & infections. Volume 9:Issue 1(2020)
• Page Start: 1881
• Page End: 1891
• Publication Date: 2020-01-01
• Subjects: Hepatitis B virus -- hepatitis B vaccine -- mother-to-child transmission -- occult hepatitis B virus infection -- post-vaccination serologic testing; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2020.1808533
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: Occult hepatitis B virus (HBV) infection (OBI) has been observed among infants born to hepatitis B surface antigen (HBsAg)-positive mothers despite successful immunoprophylaxis. This study enrolled 549 infants [349 infants received a 10μg/dose of hepatitis B vaccine (HepB), and 200 infants received 20μg/dose HepB] born to HBsAg-positive mothers with HBV DNA load >6log10 IU/mL. The anti-HBs levels in the 10μg group were significantly lower than that in the 20μg group both at 7 [652.48 (564.05-754.82) vs. 1541.72 (1268.69-1873.51) mIU/mL, P <0.001] and 12 months old [257.44 (220.29-300.88) vs. 1073.41 (839.27-1372.78) mIU/mL, P <0.001]. The OBI incidence in the 10μg group was significantly higher than that in the 20μg group at both 7 [21.55% (25/116) vs. 7.56% (9/119), P =0.002] and 12 months old [17.07% (14/82) vs. 6.90% (6/87), P =0.041]. OBI incidence in infants with anti-HBs levels <100mIU/mL was higher than that of those with anti-HBs ≥100mIU/mL [35.71% (5/14) vs. 13.12% (29/221), P =0.036]. This study showed that increasing the immunisation dose from 10μg to 20μg significantly improved anti-HBs levels and decreased OBI incidence in infants with a high maternal viral load. We recommend 20μg HepB to treat this high-risk population.