In vivo damage study of different textured breast implants. (September 2020)

• Record Type: Journal Article
• Authors: Garabedian, C.; Vayron, R.; Bricout, N.; Deltombe, R.; Anselme, K.; Bigerelle, M.
• Is Part Of: Biotribology. Volume 23(2020)
• Publication Date: 2020-09
• Subjects: Breast implant -- Texture -- in vivo damage -- Surface topography -- Debris; Biological interfaces -- Periodicals; Biomedical materials -- Periodicals; Biomechanics -- Periodicals; Tribology -- Periodicals; 610.2805
• DOI: 10.1016/j.biotri.2020.100133
• Languages: English
• ISSNs: 2352-5738

Abstract

Abstract: Certain types of breast implant texture present increased risks of anaplastic large cell lymphoma (ALCL), which results from a chronic inflammatory process. Silicone debris released from implant surfaces upon wear might be implicated in this inflammation. However, in vivo formation of such debris has not been demonstrated. Consequently, we have characterized the topographical evolution of breast implant textures after implantation at multiple scales by interferometry and X-ray micro-tomography, and a new nomenclature for implant textures, namely peaks and valleys (PV), open cavities (OC), and semi-open cavities (SOC), was established. The damage was quantified as the relative difference between the Sa of the implant and that of the explant and allowed us to specify the scale ranges at which roughness is preserved, destroyed, or created. Thus, for the first time we could compare the damage to the different categories of texture defined in our classification, which results in an erosion of peaks for PV structures, a wear of the cavity wall and of the cavity "caps" for OC and SOC structures respectively. Despite their damage, prostheses retain their original morphologies. The proposed damage mechanism for these textures leads to an erosion that would release debris, similarly to the debris mill mechanism. Highlights: In vivo damage of breast implant surface is described by a morphology at all scales. There is no complete destruction of their initial morphological structures. The proposed universal damage mechanism for all prostheses is an abrasion mechanism. This mechanism releases debris on micrometric or even sub-micrometer scales.