Firing up the cold tumors by targeting Vps34. (1st January 2020)

• Record Type: Journal Article
• Authors: Janji, Bassam; Hasmim, Meriem; Parpal, Santiago; Berchem, Guy; Noman, Muhammad Zaeem
• Is Part Of: Oncoimmunology. Volume 9:Number 1(2020)
• Publication Date: 2020-01-01
• Subjects: Autophagy -- VPS34 -- cold/hot tumors -- proinflammatory cytokines -- CCL5 -- CXCL10 -- immune landscape -- NK cells -- T CD8 lymphocytes -- cancer immunotherapy -- anti-PD-1/PD-L1 -- melanoma -- colon cancer; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2020.1809936
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published in Science Advances, we demonstrate that targeting the autophagy-related protein Vps34 switched cold immune desert tumors into hot inflamed immune-infiltrated tumors and enhanced the efficacy of anti-PD-1/PD-L1. Our study provides the preclinical rationale to set up combination immunotherapy clinical trials using selective Vps34 inhibitors and immune checkpoint blockers in melanoma and CRC.