Mechanochemical synthesis of (hetero)aryl Au(i) complexes. Issue 17 (18th August 2020)

• Record Type: Journal Article
• Authors: Ingner, Fredric J. L.; Giustra, Zachary X.; Novosedlik, Sebastian; Orthaber, Andreas; Gates, Paul J.; Dyrager, Christine; Pilarski, Lukasz T.
• Is Part Of: Green chemistry. Volume 22:Issue 17(2020)
• Page Start: 5648
• Page End: 5655
• Publication Date: 2020-08-18
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d0gc02263b
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Shake, Rattle and Gold! Mechanochemistry enables the efficient and selective synthesis of organo-Au(i ) complexes. Abstract : Growing demand for sustainable chemical syntheses casts mechanochemistry in a new light as an environmentally benign alternative to traditional solvent-based methods. Given recent interest in Au(i ) complexes for catalytic, materials, and medicinal applications, we developed a mechanochemical protocol to prepare (hetero)aryl Au(i ) complexes under green conditions. The procedure reported here uses C–H or C–B activation to afford the corresponding Au(i ) complexes in high yields. Our approach bypasses external heating, long reaction times and the use of toxic solvents. We demonstrate that mechanochemical C–H auration can be used on highly functionalised bioactive substrates. Mechanistic aspects of the C–H auration are discussed.