Microfluidic lumen-based systems for advancing tubular organ modeling. (6th August 2020)

• Record Type: Journal Article
• Authors: Virumbrales-Muñoz, María; Ayuso, José M.; Gong, Max M.; Humayun, Mouhita; Livingston, Megan K.; Lugo-Cintrón, Karina M.; McMinn, Patrick; Álvarez-García, Yasmín R.; Beebe, David J.
• Is Part Of: Chemical Society reviews. Volume 49:Number 17(2020)
• Page Start: 6402
• Page End: 6442
• Publication Date: 2020-08-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cs00705f
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. Here, we review recent microfluidic lumen-based systems and their applications in basic and translational biomedical research. Abstract : Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human pathophysiology and predict drug response, having profound implications for drug discovery and development. Herein, we review progress in the development of microfluidic lumen-based models from the 2000s to the present. The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-specific diseases. We also highlight emerging application areas, such as the lymphatic system, and close the review discussing potential future directions.