Palladium-catalyzed ionic liquid-accelerated oxidative annulation of acetylenic oximes with unactivated long-chain enols. Issue 17 (12th August 2020)

• Record Type: Journal Article
• Authors: Hu, Miao; Lin, Zidong; Li, Jianxiao; Wu, Wanqing; Jiang, Huanfeng
• Is Part Of: Green chemistry. Volume 22:Issue 17(2020)
• Page Start: 5584
• Page End: 5588
• Publication Date: 2020-08-12
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d0gc02037k
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : An NHC-palladium-catalyzed ionic liquid-accelerated oxidative annulation/functionalization with H2 O or an ionic liquid as the medium was accomplished. Abstract : A palladium-catalyzed ionic liquid-accelerated oxidative cascade annulation/functionalization of acetylenic oximes with unactivated long-chain enols under aerobic conditions was accomplished. This newly developed protocol provides the rapid and straightforward synthetic strategy for the assembly of structurally diverse isoxazole architectures under mild conditions with high atom- and step-economy and exceptional functional group tolerance. Notably, the ionic liquid acts as not only a solvent in the reaction but also provides the excess halide ions to eliminate hydrochloride from acetylenic oximes. Moreover, this catalytic system could be recycled up to eight times and reused without significant loss of the catalytic activity.