Antibacterial silver-doped calcium phosphate synthesized by an enzymatic strategy for initial caries treatment. Issue 14 (1st October 2020)

• Record Type: Journal Article
• Authors: Cao, Guizhi; Jiang, Yingying; Chen, Feng; Lu, Bingqiang; Tan, Shuo; Feng, Vivien; Qi, Shengcai; He, Shisheng; Xu, Yuanzhi; Chen, Xi
• Is Part Of: Ceramics international. Volume 46:Issue 14(2020)
• Page Start: 22466
• Page End: 22473
• Publication Date: 2020-10-01
• Subjects: Calcium phosphate -- Silver -- Biomineralization -- Enzymatic reaction -- Anti-caries; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2020.06.005
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: As a chronic and infectious disease, dental caries has become a part of the heavy burdens of individuals and society, which is featured with tooth mineral loss and mainly caused by oral bacteria. Anti-caries agent should be safe, and capable of both high bacterial inhibition and remineralization, yet very few ones can meet these requirements simultaneously. In this study, a silver-doped amorphous calcium phosphate (Ag-EACP) is prepared by a biomimetic enzymatic reaction, with the in vivo energy storage biomolecule adenosine triphosphate disodium (Na2 ATP) as the phosphorus source. Ag-EACP has an amorphous phase, with high content of ATP. The doped silver in the form of Ag + ion is stabilized against transformation, can help adjust the size of Ag-EACP. The Ag-EACP can effectively inhibit the growth of Streptococcus mutans and Lactobacillus acidophilus, two main cariogenic pathogens, both in planktonic and free states, and suppress the formation of bio-film. Moreover, this nanocomposite generates significant remineralization and micro-hardness recovery of initial caries lesion. Ag-EACP shows great anti-caries effects on initial caries lesions and is promising for caries prevention in dentistry.