Hematopoietic stem cell donor with IgA nephropathy: Challenges and management algorithm. (August 2020)

• Record Type: Journal Article
• Authors: Nampoothiri, Ram V.; Kumar, Vivek; Bharati, Joyita; Lad, Sheetal; Arora, Kajal; Malhotra, Pankaj; Lad, Deepesh
• Is Part Of: Transfusion and apheresis science. Volume 59:Number 4(2020)
• Publication Date: 2020-08
• Subjects: IgA nephropathy -- G-CSF -- Hematopoietic cell donor -- Apheresis; Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2020.102781
• Languages: English
• ISSNs: 1473-0502

Abstract

Abstract: Donor safety is of prime importance in allogeneic hematopoietic cell transplantation. The Worldwide Network for Blood and Marrow Transplantation (WBMT) standing committee on donor issues has issued a consensus statement regarding suitability criteria for related adult donors. This committee recommends that donors with a history of immune-mediated glomerulonephritis and abnormal urine tests should preferably undergo bone marrow harvest, to avoid the theoretical risk of granulocyte colony-stimulating factor (G-CSF) induced immune flare-up. We discuss here a unique situation where a related donor with a history of IgA nephropathy (IgAN) insisted on a peripheral blood stem cell harvest. We propose a management plan for this situation, which posed challenges about donor suitability.