Recent advances in photonanomedicines for enhanced cancer photodynamic therapy. (October 2020)

• Record Type: Journal Article
• Authors: Hu, Jing-Jing; Lei, Qi; Zhang, Xian-Zheng
• Is Part Of: Progress in materials science. Volume 114(2020)
• Publication Date: 2020-10
• Subjects: Photonanomedicines -- Photodynamic therapy -- Tumor targeting -- Hypoxia -- Combinational treatment; AIE aggregation-induced emission -- δ-ALA δ-aminolevulinic acid -- Ce6 chlorin e6 -- CLSM confocal laser scanning microscope -- CPPO Bis[2, 4, 5-trichloro-6-(pentyloxycarbonyl)phenyl] oxalate -- DCs dendritic cells -- DMA 2, 3-dimethylmaleic anhydride -- DNA deoxyribonucleic acid -- DOX doxorubicin -- EPR enhanced permeability and retention -- FA folic acid -- GNR gold nanorod -- HA hyaluronic acid -- Hb Hemoglobin -- HP hypoxia-activated probe -- HSA human serum albumin -- ICG indocyanine green -- LbL layer-by-layer -- mAb monoclonal antibody -- MB methylene blue -- MMP-2 matrix metalloproteinase-2 -- MOF metal–organic frameworks -- MSN mesoporous silica nanoparticle -- NIR near-infrared -- NLS nuclear localizing sequence -- NPs nanoparticles -- OPA one-photon absorption -- PCI photochemistry internalization -- PDR photodynamic reaction -- PDT photodynamic therapy -- PEG polyethylene glycol -- PFC perfluorocarbon -- PLGA poly(D, L-lactic-co-glycolic acid) -- PNMs photonanomedicines -- PpIX protoporphyrin IX -- PSs photosensitizers -- PTT photothermal therapy -- RBCs red blood cells -- ROS reactive oxygen species -- RT radiotherapy -- SCNPs scintillating nanoparticles -- SiPc silicon (IV) phthalocyanine -- TK thioketal -- TME tumor microenvironment -- TPA two-photon absorption -- TPE tetraphenylethylene -- TPP triphenylphosphonium -- TPZ tirapazamine -- UCL upconversion luminescence -- UCNPs upconversion nanoparticles -- UV ultraviolet; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2020.100685
• Languages: English
• ISSNs: 0079-6425

Abstract

Graphical abstract: Recent research advances of photonanomedicines, which can circumvent or overcome tumor-associated barriers for significantly enhanced efficiency of cancer photodynamic therapy (PDT), are reviewed in this work. Abstract: Nowadays, photodynamic therapy (PDT) that employs photosensitizers (PSs) to generate cytotoxic species under light irradiation for selective destruction of neoplastic lesions has attracted extensive research attention. Despite the significant progress of PDT, its clinical-translation is still hampered by the insufficiency of three essential elements (light, PSs, and oxygen) at tumor sites. Spurred by the current explosion of nanotechnology, developing photonanomedicines (PNMs) to overcome critical obstacles of conventional PDT has become promising. In this review, we highlight recent research advances in PNMs, which focus on enhanced efficiency of cancer PDT. The design strategies of PNMs are classified into four sections, overcoming the limited light penetration depth, increasing the local PSs concentration, tackling the hypoxic problem, as well as combining with other treatments. Furthermore, the issues and outlook of PNMs for enhanced PDT are also discussed.