Rare case of Auto immune haemolytic anaemia in an infant with auto "f & kidd antibodies". (August 2020)

• Record Type: Journal Article
• Authors: Gupta, Anubhav; Pokhrel, Anupa; Sachdeva, Prerna; Varshney, Shilpi; Arora, Harkiran; Chaudhary, Kiran; Asati, Swati
• Is Part Of: Transfusion and apheresis science. Volume 59:Number 4(2020)
• Publication Date: 2020-08
• Subjects: AIHA Auto immune Haemolytic Anaemia -- DAT Direct antiglobulin test -- CAT Column agglutination test -- CTT Conventional tube technique -- CMV Cytomegalovirus -- HSV Herpes simplex virus -- HPLC High performance liquid chromatography -- MCV Mean corpuscular volume -- IH Immunohaematology -- Mf mixed field -- Ctl control -- PRBC Packed red blood cell -- ICT Indirect coombs test -- Hb Haemoglobin; compound antigen -- AIHA -- auto f +Jka -- allogenic adsorption and elution; Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2020.102762
• Languages: English
• ISSNs: 1473-0502

Abstract

Abstract: Background: "f" antigen is a compound antigen in Rh blood group system. Anti f has haemolytic potential as described in literature. Its occurrence in an infant as autoantibody with another blood group system ie Jka is very rare. Case report We report a case of 10-month-old infant diagnosed with AIHA with autoantibodies directed towards "f" and Jka antigen. Antibody identification was done and antigen negative blood units were crossmatched & transfused with demonstrable haemoglobin rise and subsequent decrease in DAT grading. Result: Auto anti f + Jka was identified in a 10 months old infant. Autoantibodies were identified by identification 3 & 11 cell panel and select cell panel. Results were later confirmed by allogenic adsorption & elution. Patient was transfused antigen negative blood unit which lead to haemoglobin rise & gradual decrease in direct coombs test grading Conclusion: To our knowledge, this is the first case report of auto anti f + Jka having haemolytic potential in an infant which shows the importance of extensive immmunohaematology workup in providing compatible blood unit in patients with autoantibody.