Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients. Issue 8 (2nd July 2020)

• Record Type: Journal Article
• Authors: Goldman-Mazur, Sarah; Jurczyszyn, Artur; Castillo, Jorge J.; Waszczuk-Gajda, Anna; Grząśko, Norbert; Radocha, Jakub; Bittrich, Max; Kortüm, Klaus Martin; Gozzetti, Alessandro; Usnarska-Zubkiewicz, Lidia; Valls, Julio D.; Jayabalan, David S.; Niesvizky, Ruben; Kelman, Julia; Coriu, Daniel; Rosiñol, Laura; Szukalski, Łukasz; González-Calle, Veronica; Mateos, María-Victoria; Jamroziak, Krzysztof; Hus, Iwona; Avivi, Irit; Cohen, Yael; Mazur, Piotr; Suska, Anna; Chappell, Aimee; Madduri, Deepu; Chhabra, Saurabh; Kleman, Ariel; Hari, Parameswaran; Delforge, Michel; Robak, Paweł; Gentile, Massimo; Kozłowska, Izabela; Goldberg, Stuart L.; Czepiel, Jacek; Długosz-Danecka, Monika; Silbermann, Rebecca; Olszewski, Adam J.; Barth, Peter; Mikala, Gabor; Chim, Chor S.; Vesole, David H.;
• Is Part Of: Leukemia & lymphoma. Volume 61:Issue 8(2020)
• Page Start: 1885
• Page End: 1893
• Publication Date: 2020-07-02
• Subjects: Translocation -- t(14;20) -- myeloma -- survival -- MAF -- t(14;16); Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2020.1749605
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: The MAF translocations, t(14;16) and t(14;20), are considered as adverse prognostic factors based on few studies with small sample sizes. We report on their prognostic impact in a large group of 254 patients – 223 (87.8%) with t(14;16) and 31 (12.2%) with t(14;20). There were no intergroup differences in survival estimates. Median progression-free survival was 16.6 months for t(14;16) and 24.9 months for t(14;20) ( p = 0.28). Median overall survival (OS) was 54.0 months and 49.0 months, respectively ( p = 0.62). Median OS in patients who underwent double autologous stem cell transplantation (ASCT) was 107.0 months versus 60.0 months in patients who received single ASCT ( p < 0.001). ISS 3 was associated with shorter OS (HR = 1.89; 95% CI 1.24–3.19; p = 0.005) in Cox analysis. Our study suggests that t(14;20) should be considered as an adverse factor of equal prognostic implication to t(14;16).