Inter-ethnic differences in normal coronary anatomy between Caucasian (Polish) and Asian (Korean) populations. Issue 130 (September 2020)

• Record Type: Journal Article
• Authors: Skowronski, Jaroslaw; Cho, Iksung; Mintz, Gary S.; Wolny, Rafal; Opolski, Maksymilian P.; Cha, Min Jae; Lee, Wang Soo; Michalowska, Ilona; Kepka, Cezary; Kruk, Mariusz; Tyczynski, Pawel; Kalinczuk, Lukasz; Kukula, Krzysztof; Ciszewski, Michal; Banasiak, Adam; Chmielak, Zbigniew; Witkowski, Adam; Kim, Sang-Wook; Pregowski, Jerzy
• Is Part Of: European journal of radiology. Issue 130(2020)
• Publication Date: 2020-09
• Subjects: CAD coronary artery disease -- ICA invasive coronary angiography -- LMCA left main coronary artery -- IVUS intravascular ultrasound -- CTA computed tomography angiography -- CKD chronic kidney disease -- GFR glomerular filtration rate -- BSA body surface area -- RCA right coronary artery -- PDA posterior descending artery -- LCA left coronary artery -- OM obtuse marginal -- LAD left anterior descending artery -- LCX left circumflex artery -- LD lumen diameter -- LA lumen area -- ICC interclass correlation coefficient -- MSA minimal stent area; Coronary computed tomography angiography -- Coronary artery anatomy -- Inter-ethnical difference -- Coronary artery disease -- Atherosclerosis risk factor; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2020.109185
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Asians have smaller atherosclerosis-free proximal coronary arteries than Caucasians. Ethnicity, sex and anatomical dominance predict dimensions of coronary arteries. The inter-ethnic differences may influence the management of coronary artery disease. Abstract: Purpose: Little is known about ethnic differences in the size of coronary arteries in disease-free individuals. Our aim was to compare coronary artery dimensions between Asian and Caucasian population without atherosclerosis. Methods: One hundred and twelve Caucasian patients without any discernible atherosclerosis detected on coronary computed tomography angiography were matched with 112 Asian patients using sex, age, coronary dominance pattern and body surface area (BSA). Maximal and minimal lumen areas (LA) and diameters (LD) of proximal and middle coronary segments were measured, and the mean values were used for analyses. Results: Caucasians had larger LA and LD than Asian patients in all proximal coronary segments. Overall, the mean difference in LA and LD was 11.4 % and 5.2 %, respectively. Significant differences were observed for all proximal segments (left anterior descending: 13 % and 6%, left circumflex 14 % and 8% and right coronary artery 8% and 4% for LA and LD), but not for mid segments. The greatest difference between Caucasians and Asians was found in left main coronary artery (LMCA) LA (21.2 ± 6.5 vs.16.8 ± 5.4 mm 2, p < 0.01 respectively). The independent predictors of larger LA and LD of LMCA and proximal coronary segments were male sex (p < 0.05), Caucasian ethnicity (p < 0.05), and left dominance pattern (p < 0.05). Conclusion: In subjects without atherosclerosis, Asians have smaller dimensions of all proximal coronary arteries, most prominently displayed in LMCA, than the Caucasians regardless of age, sex, or body size.