High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats. (26th May 2020)

• Record Type: Journal Article
• Authors: Khakdan, Soheyla; Delfan, Maryam; Heydarpour Meymeh, Maryam; Kazerouni, Faranak; Ghaedi, Hamid; Shanaki, Mehrnoosh; Kalaki-Jouybari, Fatemeh; Gorgani-Firuzjaee, Sattar; Rahimipour, Ali
• Is Part Of: Archives of physiology and biochemistry. Volume 126:Number 3(2020)
• Page Start: 250
• Page End: 257
• Publication Date: 2020-05-26
• Subjects: Diabetic cardiomyopathy -- microRNA-195 -- myocardial function -- high-intensity interval training -- continuous endurance training; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2018.1511599
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard. Methods: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT). After eight weeks of running, expression of miR-195 and myocardial function were evaluated. Results: HIIT effectively decreases the expression of miR-195 and increases the expression of Sirt1 and BCL-2 in diabetic rats compared with CET. Our results showed that HIIT compared with CET increases left ventricular ejection fraction (LVEF%) and fractional shortening (FS%). Conclusions: Our results indicated that exercise, especially HIIT is an appropriate strategy for reducing miR-195 and improving myocardial function in diabetic rats compared with CET.