Antiviral effects of statins. (July 2020)

• Record Type: Journal Article
• Authors: Gorabi, Armita M.; Kiaie, Nasim; Bianconi, Vanessa; Jamialahmadi, Tannaz; Al-Rasadi, Khalid; Johnston, Thomas P.; Pirro, Matteo; Sahebkar, Amirhossein
• Is Part Of: Progress in lipid research. Volume 79(2020)
• Publication Date: 2020-07
• Subjects: Statins -- Virus -- Infection -- Pleiotropic -- Cholesterol; ABCA1 ATP binding cassette transporter A1 -- APCs antigen presenting cells -- CCR5 C-C chemokine receptor type 5 -- CMV cytomegalovirus -- CXCR4 C-X-C chemokine receptor type 4 -- CYP3A4 cytochrome P450 3A4 -- DCs dendritic cells -- DENV Dengue virus -- FBL2 F-box/LRR-repeat protein 2 -- HCV hepatitis type C virus -- HIV-1 human immunodeficiency virus type 1 -- HMG-CoA hydroxy-3-methylglutaryl coenzyme A -- HSP heat shock protein -- HUVECs human umbilical vein endothelial cells -- GGP geranylgeranyl pyrophosphate -- Gp glycoprotein -- HBV hepatitis type-B virus -- ICAM-1 intercellular adhesion molecule-1 -- IFN-α interferon alpha -- IFN-γ interferon gamma -- LDLR low-density lipoprotein receptor -- LFA-1 leukocyte function-associated antigen-1 -- MHCI class I major histocompatibility complex -- Mn-SOD Manganese superoxide dismutase -- MVD mevalonate (diphospho) decarboxylase -- NHBE human bronchial epithelial cells -- NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells -- NO nitric oxide -- NOV norovirus -- NS5A nonstructural protein 5A -- Nup98 nucleoporin 98 -- Rae1 ribonucleic acid export 1 -- ROS reactive oxygen species -- RSV respiratory syncytial virus -- SREBF-2 sterol-responsive element-binding factor 2 -- STED-FCS super-resolution scanning fluorescence correlation spectroscopy -- SVR sustained virological response -- TNF tumor necrosis factor -- VSV vesicular stomatitis virus; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipiden; 572.57
• DOI: 10.1016/j.plipres.2020.101054
• Languages: English
• ISSNs: 0163-7827

Abstract

Abstract: Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle ( i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.