Is vitamin D deficiency a risk factor for recurrent aphthous stomatitis? A systematic review and meta‐analysis. (8th October 2019)

• Record Type: Journal Article
• Authors: Al‐Maweri, Sadeq Ali; Halboub, Esam; Al‐Sufyani, Ghadah; Alqutaibi, Ahmed Yaseen; Shamala, Anas; Alsalhani, Anas
• Is Part Of: Oral diseases. Volume 26:Number 6(2020)
• Page Start: 1116
• Page End: 1123
• Publication Date: 2019-10-08
• Subjects: aphthous stomatitis -- correlation -- risk factor -- vitamin D; Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.13189
• Languages: English
• ISSNs: 1354-523X

Abstract

Abstract: Objectives: A few studies have associated vitamin D deficiency with the occurrence of recurrent aphthous stomatitis (RAS). Hence, the aim of the present systematic review and meta‐analysis is to explore such a potential association. Methods: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted in June 2019. The inclusion criteria were (a) observational studies that assessed the relationship between vitamin D and RAS, and (b) the outcome measures reported quantitative vitamin D levels. Studies without control groups, case series, case reports, experimental studies, letter to editors, reviews, were excluded. The random effects model was conducted for meta‐analyses using RevMan 5.3 software. Results: Five studies comprising 208 RAS patients and 241 healthy individuals were included. All studies except one reported significantly lower levels of vitamin D in RAS patients compared with the healthy individuals. The results of the pooled 5 studies revealed statistically significant lower levels of vitamin D in RAS patients (Mean Difference (MD) = −9.67 ng/ml, 95% CI = −15.68, −3.65; p ˂ .002). Conclusion: The present meta‐analysis suggests a significant association between low vitamin D levels and RAS. Further well‐designed studies with adequate sample sizes are required to elucidate the role of vitamin D in pathogenesis of RAS.