Nanosized Phase‐Changeable "Sonocyte" for Promoting Ultrasound Assessment. Issue 34 (22nd July 2020)

• Record Type: Journal Article
• Authors: Xu, Yurui; Lu, Qiangbing; Sun, Lei; Feng, Shujun; Nie, Yuanyuan; Ning, Xinghai; Lu, Minghui
• Is Part Of: Small. Volume 16:Issue 34(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-22
• Subjects: clinical applications -- nanoerythrocyte -- perfluorocarbon -- phase transitions -- ultrasound imaging; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202002950
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Despite the ability of microbubble contrast agents to improve ultrasound diagnostic performance, their application potential is limited due to low stability, fast clearance, and poor tissue permeation. This study presents a promising nanosized phase‐changeable erythrocyte (Sonocyte), composed of liposomal dodecafluoropentane coated with multilayered red blood cell membranes (RBCm), for improving ultrasound assessments. Sonocyte is the first RBCm‐functionalized ultrasound contrast agent with uniform nanosized morphology, and exhibits good stability, systemic circulation, target‐tissue accumulation, and even ultrasound‐responsive phase transition, thereby satisfying the inherent requirement of ultrasound imaging. It is identified that Sonocyte displays similar sensitivity as microbubble SonoVue, a clinical ultrasound contrast agent, for effectively detecting normal parenchyma and hepatic necrosis. Importantly, compared with SonoVue lacking of ability to detect tumors, Sonocyte can identify tumors with high sensitivity and specificity due to superior tumor accumulation and penetration. Therefore, Sonocyte exhibits superior capabilities over SonoVue, endowing with a great clinical application potential. Abstract : A phase‐changeable Sonocyte is successfully prepared and applied in ultrasound imaging for diseases related to abnormal hemoperfusion. Sonocyte is liposomal nanodroplets coated with multilayered red blood cell membranes, which not only improve stability, but also endow with good target accumulation. Importantly, Sonocyte exhibits preferable ability to diagnose liver necrosis and tumor over clinical SonoVue, indicating its high clinical application potential.