Potential association between oral mucosal nevus and melanoma: A preliminary clinicopathologic study. (13th April 2020)

• Record Type: Journal Article
• Authors: Liu, Wei; Wang, Yang; Du, Guanhuan; Zhou, Zengtong; Yang, Xi; Shi, Linjun
• Is Part Of: Oral diseases. Volume 26:Number 6(2020)
• Page Start: 1240
• Page End: 1245
• Publication Date: 2020-04-13
• Subjects: clinicopathologic feature -- junctional nevus -- malignant risk -- nevus‐associated melanoma -- oral mucosal nevi; Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.13335
• Languages: English
• ISSNs: 1354-523X

Abstract

Abstract: Objectives: To assess potential association between oral nevi (ON) and nevus‐associated melanoma (NAM), in which melanoma cells coexist with nevus cells. Methods: A total of 74 ON patients and 7 NAM patients were retrospectively reviewed. Comparative and regression analyses of clinical and histological data were performed between two groups. Results: The mean age of the patients with ON was 36.5 years compared with that of 54.7 years of the patients with NAM ( p = .008). Gender ratio was female predominance for ON (1.64:1 ratio) and male predominance for NAM (6:1 ratio). The most common location of ON and NAM was the palate (31.1%) and gingiva (71.4%), respectively. Univariate regression analysis revealed that elderly male patients (≥60 years) with junctional ON located on the gingiva correlate with higher risk of melanoma. Multivariate analysis revealed that junctional type of ON was an independent factor (adjusted OR, 38.32; 95% CI, 3.20–458.64; p = .004) associated significantly with increased risk for melanoma. Conclusions: The preliminary study for the first time elucidated the clinicopathologic features of a Chinese series of ON and evaluated the potential association between ON and NAM with a limited sample size. Further large multicenter studies are needed to confirm the findings.