Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Lee, Hsiang-Ping; Wu, Yang-Chang; Chen, Bo-Cheng; Liu, Shan-Chi; Li, Te-Mao; Huang, Wei-Chien; Hsu, Chin-Jung; Tang, Chih-Hsin
• Is Part Of: Food and agricultural immunology. Volume 31:Issue 1(2020)
• Page Start: 740
• Page End: 750
• Publication Date: 2020-01-01
• Subjects: Soya-cerebroside -- rheumatoid arthritis -- IL-1β -- IL-6 -- IL-8; Immunochemistry -- Periodicals; Food -- Analysis -- Periodicals; Immunoassay -- Periodicals; 616.079
• DOI: 10.1080/09540105.2020.1766426
• Languages: English
• ISSNs: 0954-0105

Abstract

ABSTRACT: Rheumatoid arthritis (RA) is characterised by the infiltration of a number of proinflammatory cytokines into synovial fluid. Soya-cerebroside, an extract from Cordyceps militaris, inhibits synovial inflammation and reduces cartilage damage in an osteoarthritis model, although the role of soya-cerebroside in inflammatory cytokine expression in RA is uncertain. In this study, Gene Expression Omnibus (GEO) database records revealed higher levels of interleukin (IL)-1β, IL-6 and IL-8 in RA tissue compared with normal tissue. Elevated levels of these inflammatory cytokines were also higher in mice with collagen-induced arthritis (CIA) than in control mice. Soya-cerebroside effectively inhibited IL-1β, IL-6 and IL-8 expression in RA synovial fibroblasts, apparently by inhibiting the ERK, NF-κB and AP-1 signalling pathways. This anti-inflammatory agent shows promise for the treatment of RA.