Synthesis and anticholinesterase activities of novel glycosyl benzoxazole derivatives. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Wu, Yu-Ran; Ren, Shu-Ting; Wang, Lei; Wang, You-Xian; Liu, Shu-Hao; Liu, Wei-Wei; Shi, Da-Hua; Cao, Zhi-Ling
• Is Part Of: Journal of chemical research. Volume 44:Issue 7/8(2020)
• Page Start: 363
• Page End: 366
• Publication Date: 2020-07
• Subjects: benzoxazole -- cholinesterase inhibitory activity -- glucosamine; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/1747519819901251
• Languages: English
• ISSNs: 1747-5198

Abstract

Eight glycosyl benzoxazole derivatives are synthesized by nucleophilic addition reactions of glycosyl isothiocyanate with o -aminophenol in tetrahydrofuran. The reaction conditions are optimized, and good yields (86%–94%) were obtained. The structures of all new products are confirmed by infrared, 1 H nuclear magnetic resonance, and high-resolution mass spectrometry (electrospray ionization). In addition, the in vitro cholinesterase inhibitory activities of these new compounds are tested by Ellman's method.