Host CD8α+ and CD103+ dendritic cells prime transplant antigen‐specific CD8+ T cells via cross‐dressing. Issue 7 (8th June 2020)

• Record Type: Journal Article
• Authors: Li, Bin; Lu, Chunni; Oveissi, Sara; Song, Jing; Xiao, Kun; Zanker, Damien; Duan, Mubin; Chen, Jianxin; Xu, Huji; Zou, Quanming; Wu, Chao; Yewdell, Jonathan W; Chen, Weisan
• Is Part Of: Immunology and cell biology. Volume 98:Issue 7(2020)
• Page Start: 563
• Page End: 576
• Publication Date: 2020-06-08
• Subjects: CD8α -- CD103 -- cross‐dressingdendritic cells -- priming -- T cells -- transplant antigen; Immunology -- Periodicals; Cytology -- Periodicals; 616.079
• DOI: 10.1111/imcb.12342
• Languages: English
• ISSNs: 0818-9641

Abstract

Abstract: The participation of dendritic cells (DCs) in CD8 + T‐cell‐mediated allograft rejection is a long‐standing question of great clinical relevance for tissue transplantation. Here, we show that Batf3 −/− mice demonstrate delayed allo‐skin graft rejection and are deficient in priming allo‐specific CD8 + T cells. Batf3 −/− mouse priming is restored by transferring either purified CD8α + or CD103 + DCs, demonstrating the critical role of these cells in alloreactivity. Using D b ‐restricted antiviral F5 transgenic T‐cell receptor T cells, which we demonstrate are alloreactive with H‐2K d, we show that cross‐dressing of CD8α + and CD103 + primes CD8 + T‐cell or allo‐specific responses in vitro and in vivo . These findings suggest novel strategies for moderating tissue rejection based on interfering with DC cross‐dressing or subsequent interaction with T cells. Abstract : This study is the first definitive demonstration of the identity of priming dendritic cells in allorecognition in mice and allo‐major histocompatibility complex–peptide cross‐dressing under physiological conditions. See also: News and Commentary bySegura