Force networks, torque balance and Airy stress in the planar vertex model of a confluent epithelium. (13th May 2020)

• Record Type: Journal Article
• Authors: Jensen, Oliver E.; Johns, Emma; Woolner, Sarah
• Is Part Of: Proceedings. Volume 476:Number 2237(2020)
• Publication Date: 2020-05-13
• Subjects: vertex model -- discrete calculus -- cellular biomechanics; Physical sciences -- Periodicals; Engineering -- Periodicals; Mathematics -- Periodicals; 500
• DOI: 10.1098/rspa.2019.0716
• Languages: English
• ISSNs: 1364-5021

Abstract

Abstract : The vertex model is a popular framework for modelling tightly packed biological cells, such as confluent epithelia. Cells are described by convex polygons tiling the plane and their equilibrium is found by minimizing a global mechanical energy, with vertex locations treated as degrees of freedom. Drawing on analogies with granular materials, we describe the force network for a localized monolayer and derive the corresponding discrete Airy stress function, expressed for each N -sided cell as N scalars defined over kites covering the cell. We show how a torque balance (commonly overlooked in implementations of the vertex model) requires each internal vertex to lie at the orthocentre of the triangle formed by neighbouring edge centroids. Torque balance also places a geometric constraint on the stress in the neighbourhood of cellular trijunctions, and requires cell edges to be orthogonal to the links of a dual network that connect neighbouring cell centres and thereby triangulate the monolayer. We show how the Airy stress function depends on cell shape when a standard energy functional is adopted, and discuss implications for computational implementations of the model.