Optimization of the Synthesis of 18F‐D2‐Deprenyl With Mild 18F‐Fluorination and Minimum Precursor Input for PET Imaging of Neuroinflammation. (11th August 2020)

• Record Type: Journal Article
• Authors: Lee, Sang Ju; Ko, Na Re; Oh, Seung Jun
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 41:Number 8(2020)
• Page Start: 805
• Page End: 811
• Publication Date: 2020-08-11
• Subjects: 18F‐fluorination -- 18F‐D2‐deprenyl -- PET imaging -- Neuroinflammation -- Positron emission tomography; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.12071
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract : Here, we established optimized conditions for a mild 18 F‐fluorination to yield 18 F‐deprenyl and 18 F‐D2 ‐deprenyl as neuroinflammation imaging agents by fully automatic synthesis. Initially, manual synthesis with 1 mg of precursor and pH = 7.8 KOMs elution buffer yielded 85–92% of 18 F‐incorporation yields and showed nondecay corrected yields of 15–17%. Fully automatic synthesis showed a nondecay corrected radiochemical yield of 10.7 ± 0.46%. Owing to low precursor input, the maximum molar activity achieved was 1302.4 ± 26.4 GBq/μmol. Our mild 18 F‐fluorination procedure showed higher radiochemical yields and molar activity than those by previously used procedures, even with minimized precursor input. Abstract : Radiochemical synthesis of 18F‐deprenyl and 18F‐D2‐deprenyl.