Combinational Chemotherapy and Photothermal Therapy Using a Gold Nanorod Platform for Cancer Treatment. (8th July 2020)

• Record Type: Journal Article
• Authors: Shukla, Nutan; Singh, Baljinder; Kim, Ho‐Joong; Park, Myoung‐Hwan; Kim, Kibeom
• Is Part Of: Particle and particle systems characterization. Volume 37:Number 8(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-08
• Subjects: chemotherapy -- combinational therapy -- gold nanorods -- photothermal therapy -- synergistic effects; Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.202000099
• Languages: English
• ISSNs: 0934-0866

Abstract

Abstract: Multimodal approaches combined with various nanomaterials and advanced techniques have been developed for synergistic cancer treatment. Among various therapies, conventional chemotherapy (CHT) is a direct cancer treatment that can produce unintended side effects due to nonspecific action on both the tumor and normal cells; patient‐friendly photothermal therapy (PTT) may be able to treat embedded tumors in vital regions with minimal invasion but does not guarantee complete removal of cancers. However, the combination of CHT‐PTT may provide a promising tool for direct cancer treatment with minimal side effects. In this regard, nanostructured materials, such as gold nanorods with tuned size and surface characteristics, are key components designed to enhance the heating capacity and active or passive delivery of drugs to the tumor site. In this review, the pioneering work synergizing CHT and PTT is summarized, and the current state‐of‐the‐art in the development of inorganic and organic nanocomposites for combinational therapy is described. Abstract : The combination of chemotherapy (CHT) and photothermal therapy (PTT) has been developed to complement deficiencies of CHT and PTT alone. In particular, gold nanorod (GNR)‐based templates have advantages in combination therapies because of the intrinsic properties of GNRs. In this review, various GNR‐based combined therapies of CHT‐PTT are summarized.