Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health. Issue 1 (9th November 2020)

• Record Type: Journal Article
• Authors: Mukherjee, Arghya; Lordan, Cathy; Ross, R. Paul; Cotter, Paul D.
• Is Part Of: Gut microbes. Volume 12:Issue 1(2020)
• Publication Date: 2020-11-09
• Subjects: Eubacterium -- gut microbiota -- short-chain fatty acids -- Eubacterium hallii -- Eubacterium rectale -- butyrate -- irritable bowel syndrome -- phylogeny -- bile acids -- cholesterol; Gastrointestinal system -- Microbiology -- Periodicals; Microbiology -- Periodicals; Intestine, Small -- Periodicals; 616.3
• DOI: 10.1080/19490976.2020.1802866
• Languages: English
• ISSNs: 1949-0984

Abstract

ABSTRACT: Over the last two decades our understanding of the gut microbiota and its contribution to health and disease has been transformed. Among a new 'generation' of potentially beneficial microbes to have been recognized are members of the genus Eubacterium, who form a part of the core human gut microbiome. The genus consists of phylogenetically, and quite frequently phenotypically, diverse species, making Eubacterium a taxonomically unique and challenging genus. Several members of the genus produce butyrate, which plays a critical role in energy homeostasis, colonic motility, immunomodulation and suppression of inflammation in the gut. Eubacterium spp. also carry out bile acid and cholesterol transformations in the gut, thereby contributing to their homeostasis. Gut dysbiosis and a consequently modified representation of Eubacterium spp. in the gut, have been linked with various human disease states. This review provides an overview of Eubacterium species from a phylogenetic perspective, describes how they alter with diet and age and summarizes its association with the human gut and various health conditions.