Isolation, semi-synthesis, free-radicals scavenging, and advanced glycation end products formation inhibitory constituents from Parmotrema tinctorum. Issue 10 (2nd October 2020)

• Record Type: Journal Article
• Authors: Pavan Kumar, P.; Siva, Bandi; Anand, Ajay; Tiwari, Ashok K; Vekata Rao, C.; Boustie, Joel; Suresh Babu, K.
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 10(2020)
• Page Start: 976
• Page End: 988
• Publication Date: 2020-10-02
• Subjects: AGEs inhibition -- antioxidant activity -- lichen substance -- Parmotrema tinctorum -- semi-synthetic derivatives; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1628024
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Bioassay-guided separation of acetone extract from lichen Parmotrema tinctorum (Delise ex Nyl.) Hale led to the isolation of six major phenolic constituents (1–6 ). Compounds structures were established using NMR and mass spectral techniques. Further, to develop libraries on these scaffolds, a series of semi-synthetic derivatives were prepared (1a–1f, 2a–2b, 3a, 5a ) and investigated for their free-radicals (2, 2-diphenyl-1-picrylhydrazyl and 2, 2′-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)) scavenging and advanced glycation end products (AGEs) formation inhibitory activities. Amongst tested derivatives, 1a, 1d, 1e, 2a, and 5a showed strong ABTS scavenging potentials comparable to Trolox. In addition, these derivatives also manifested moderate AGEs formation inhibitory activities.