Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy. Issue 69 (29th July 2020)

• Record Type: Journal Article
• Authors: Zhang, Yanhua; Liu, Xi; Lin, Yun; Lian, Baoping; Lan, Wenjun; Iovanna, Juan L.; Liu, Xiaoxuan; Peng, Ling; Xia, Yi
• Is Part Of: Chemical communications. Volume 56:Issue 69(2020)
• Page Start: 10014
• Page End: 10017
• Publication Date: 2020-07-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc04660d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Novel triazole nucleosides developed by the strategy of "terminal N, N -dimethylation" displayed anticancer activity mediated via apoptosis and autophagy. Abstract : Novel nucleoside derivatives were developed using the strategy of "terminal N, N -dimethylation" to impart tertiary amines to a 1, 2, 4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates.