Divergent synthesis of 1, 3, 5-tri and 1, 3-disubstituted pyrazoles under transition metal-free conditions. Issue 33 (12th August 2020) - Ma, Liyao
Abstract : Pyrazole cores are common structural motifs existing in various agrochemicals and pharmaceuticals. Abstract : Pyrazole cores are common structural motifs existing in various agrochemicals and pharmaceuticals. Herein, a transition metal-free, three-component reaction of arylaldehydes, ethyl acrylate and N -tosylhydrazones is described, which leads to the formation of 1, 3, 5-trisubstituted and 1, 3-disubstituted pyrazoles divergently under slightly different conditions.